Contraindicated (one)pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with potent CYP3A4 inducers; these medications reduce publicity to vandetanib by around 40%.pentobarbital will reduce the extent or effect of eltrombopag by affecting hepatic e

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